Hormonal Study of Primary Infertile Women


Ban Mousa Rashid1, Tayfoor Jalil Mahmoud2, Beston F. Nore3

1,3 Faculty of Medical Sciences, University of Sulaimani, 2 College of Medicine, Hawler Medical University



Abstract
Approximately (15 %) of couples attempting their first pregnancy meet with failure. Most authorities define these patients as being primary infertile if they unable to achieve a pregnancy after one year of unprotected intercourse. The aim of this study was to evaluate the serum levels of Luteinizing hormone, Follicle stimulating hormone, Prolactin and Testosterone in (410) primary infertile women in Sulaimani city. The results obtained compared with that of (240) age matched fertile women. The results showed, higher incidence of primary infertility was in the age range (26-37) years and hormonal imbalance plays an important role in primary female infertility. 
Keywords: Primary female infertility, LH, FSH, PRL, Testosterone. 


References 
1-Abraham S., Oats J. and Llewellyn-Jones; Fundamentals of obstetrics and gynecology; 8th ed.: Elsevier Mosby, p 255-315, (2005).  
2-Berek S. J. Novak’s Gynocology: Infertility, 13th ed., Chapter 27, pp 973-83, Lipincott Williams and Wilkins, (2002). 
3-Balen A. H. and Rutherford A. J. Management of infertility. J. Mol. Biol., 335: 60811. (2007). 
4-Sanders B. Uterine factors and infertility. J. Reorod. Med., 51: 169-76, (2006). 
5-Gronovski A. M., Fantz C. R., Parvin C. A., Sokoll L. J., Wiley C. L., Wener M. H., and Grenache D. G. Use of serum FSH to identify pre- menopausal women with pituitary hCG, Clin. Chem., 54: 652-56, (2008). 
6-Heinonen P. K., and Pystynen P. P. Primary infertility and uterine anomalies. Fertil. Steril., 40, 311-17, (1983). 
7-Al-Inany H. Female infertility, Clin. Evid., 15: 2465-87, (2006). 
8-Falkenberry S. S. Nipple discharge. Obstet, Gynecol. Clin. North. Am., 29: 21-30, (2002). 
9-Sensky T. E., and Liu D. T. Endometriosis association with menorraghia, infertility and oral contraceptives. Intnat. J. Gynocol. Obestet., 17:    573-76, (1980). 
10-Mardh P. A., Tubal factor infertility, with special regard to chlamydial salpingitis, Current Opin. Infect. Dis., 17: 49-52, (2004).  
11-Pellicer A., Albert C. and Garrido N., The pathophysiology of endometriosisassociated infertility: Follicular environment and embryo    quality, J. Reprod. Fert. Suppl., 55: 109-19, (2000). 
12-Ross G. T., and Vande-Wiele L. Textbook of endocrinology, pp-368, W, B. Saunders Co. Philadelphia, (1974). 
13-Buckman M. T., Peake G. T. and Srivastava L. Pattern of spontaneous LH release in normo and hyperprolactinemic women, Acta    Endocrinol., 97: 305-10, (1981). 
14-Davis S. R., and Tran J. What are normal testosterone levels for women? J. Clin. Endocrinol. Metab., 86: 1842-46, (2001). 
15-Davis S. R., and Tran J. Testosterone influences libido and wellbeing in women. Trends Endocrinol. Metab., 12: 33-40, (2001). 
16-Woodman D. D. Laboratory animal endocrinology, Chichester, U.K., (1997). 
17-Bole-feysot C., Goffin V., Edery M., Binart N., and Kelly P. A. Prolactin and its receptor: Actions signal transduction pathway and    phenotypes observed in PRL receptor knockout mice, Endocrinol. Rev., 19: 225-68, (1998).  
18-Yen S. S. C., Faffe R. B., and Berbieri R. L. Reproductive endocrinology, 4th ed., pp 257-83 W, B, Saunders Co, Philadelphia, (1999). 
19-Biller B. M. Diagnostic evaluation of hyperprolacinemia, J. Reprod. Med., 44: 1095-99, (1999). 
20-Ban M. R. Hormonal study and DNA sequencing in infertile women. Ph. D. thesis, University of Sulaimani, College of Science, (2010). 
21-Scott M. G. and Ladenson J. H. Hormonal evaluation of female infertility and reproductive disorders. Clin. Chem., 35:620-29, (1989). 
22-Griswold M. D. Actions of FSH on mammalian sertoli cells, pp496-508, L. D. Russell and M. D. Griswold ed., (1993). 
23-Casanueva F. F, Molitch M. E. and Schlechte J. A. Guidelines of the pituitary society for the diagnosis and management of prolactin. Clin.    Endocrinol. Oxf., 65: 265-338, (2006). 
24-Roupa Z., Polikandrioti M.,Sotiropoulou P., Faros E., Koulouri A., Wozniak G. Causes of infertility in women at reproductive age, Health  Science J., 3: 80-7, (2009). 
25-Xie Y., and Ellen E. P. Age patterns of marital fertility: Revising the CoaleTrussell Method. J. Amer. Statis. Associat., 87: 977-84, (1992). 
26-Coale A. J., and Trussll T. J. Variations in the age structure of childbearing in human populations. Population Index, 40: 185-258, (1974). 
27-Hull M. G., Glazener C. M., Kelly N. J., Conway D. I., Foster P. A.,and Hinton R. A. Population study of causes, treatment, and outcome of    infertility. Br. Med. J., 291: 1693-700, (1985). 
28-Siiteri P. K. and Simberg N. H. Changing concepts of active androgens in blood. Clin. Endocrinol. Metab., 15: 247-58, (1986). 
29-Van Santbrink E. J., Hop W. C., and Fauser B. C. Classification of normogonadotrpic infertility: Polycyclic ovary syndrome, Fertil. Steril., 67:  452-8, (1997). 
30-Greenblat R. B., Barfield W. E., Jungck E. C., and Ray A. W. Induction of ovulation with MRL /41. JAMA, 178: 127-30, (1961). 
31-Frantz A. G. Prolactin and its functions., J. A. Parson ed., pp 199, University Park Press, Baltimore, (1975). 
32-Josinovich J. B., Renolds M., and Cobo E. Lactogenic hormone, fetal, nutrition, and lactation, ed. John Wiley and Sons, pp 111, New York,  (1975). 
33-Eric M. J., Ruben P. and Nira Ben-Jonathan. Small. Molecule Inhibitors of the Prolactin Receptor in Breast Cancer, the Open Conference    Proceedings Journal, 1, 39-45, (2010). 
34-Stallings J. F., Worthman C. M., Panter-Brick C., and Coates R. J. Prolactin response to suckling and maintenance of postpartum    amenorrhea among intensively breastfeeding Nepali women, Endocr. Res, 22: 1-28, (1996). 
35-Shirtcliff E. A., and Granger D. A. Gender differences in the validity of testosterone measured in saliva by immunoassay. Horm. Behav., 42:   62-71, (2002).  
36-Lobo R. A. Androgens in post menopausal women: Production, possible role, and replacement options. Obstet. Gynecol. Surv., 56: 361-  437, (2004).