Hemodynamic and renal effects of bosentan and losartan in 2k1c hypertensive rats.

Sarkawt Hamad and Ismail Maulood
Biology Department, Faculty of Science, Soran University, Soran, Iraq;
Biology Department, College of Science, Salahaddin University, Erbil, Iraq


Endothelin-1 (ET-1) and Angiotensin II (Ang II) play important roles in generating
hypertension. The present work was investigated the hemodynamic and renal effects of
both ET-1 and Ang II on 2K1C rats. The design of this study included five groups of rats:
Group 1 Sham rats, Group 2 Normotensive rats (2K1C(n)), Group 3 two kidney one clip
hypertensive rats (2K1C(h)), Group 4 two kidney one clip hypertensive rats + Bosentan
(2K1C(h) + Bosentan), and Group 5 two kidney one clip hypertensive rats + Losartan
(2K1C(h) + Losartan). Systolic blood pressure (SBP) was significantly elevated in 2K1C(h)
rats from third to sixth week after surgery compared with control rats. SBP significantly
fell in bosentan and losartan treated rats. Serum nitric oxide (NO) level in hypertensive
rats was slightly decreased, whereas in losartan group it was significantly increased.
Serum malonaldehyde (MDA) significantly increased in bosentan treated rats as
compared to hypertensive rats. Bosentan administration caused a markedly increased in
Na+excretion rate compared with 2K1C(h) rats in week four after surgery. In conclusion,
losartan is more potent than bosentan in reducing hypertension via elevation of serum
NO level.

Key Words:
2K1C Goldblatt mode,
Systolic blood pressure


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