Zones of maximum discontinuity in the western house mouse (M. m. domesticus) genetic landscape: a computational geometry method.

Fatah Zarei and Ridha H. Hussein

Graduate Student of Systematic Zoology, Faculty of Biological Sciences, Shahid Beheshti University-Tehran, Iran
Zoology Assistant Professor, Department of Biology, School of Science, Sulaimani University, Sulaymaniyah-Iraq


To represent the zones of maximum genetic discontinuity in a network of geographically
located populations of western house mouse from the previously published mitochondrial
DNA D-loop sequence datasets which we acquired from the NCBI GenBank database,
we applied a computational geometry approach using the Monmonier’s maximum
difference algorithm implemented in the BARRIER 2.2 software. We defined ten zones
where genetic change among populations is locally increased, three of them occur within
the Middle East, while seven occur in Europe. Analysis of molecular variance among
post-hoc defined regions using the pattern generated by the BARRIER analysis showed
that a significant portion of the genetic diversity was because of among groups

Key Words:
BARRIER analysis
Genetic discontinuity
Monmonier’s algorithm
Western house mouse


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