Relation of Blood Group, Crowding Index and Family History of Dyspepsia with Helicobacter pylori Infection


Mohammad O. Mohammad, Hadeel A. Ibrahim, Taha A. Al Karboly, Hewa A. Hussein, Abdullah S. Delmany, Aras L.Qaradaghi

School of Medicine. University of Sulaimani,
School of Nursing. University of Sulaimani,
Kurdistan Center for Gastroenterology and Hepatology

DOI: https://doi.org/10.17656/jzs.10561

Abstract

Background: Dyspepsia is a common problem that frequently associated with gastritis. The risk of acquiring Helicobacter pylori is related with living conditions and the family's socioeconomic status. Thus, a relation between the H. pylori infection and group O blooded individuals was discovered. Currently, no published data available regarding the association of blood group, crowding index and family history of dyspepsia with H. pylori infection in Kurdistan region. So this study aims to assess the blood group, crowding index and family history of dyspepsia among patients with H. pylori infection.
Patients and methodology: Exactly One hundred dyspeptic patients with anti H. pylori Immunoglobulin G (IgG) positive underwent gastroscopy and 75 apparently healthy individuals with no dyspepsia and negative H. pylori IgG antibodies (escorts of patients) using Enzyme-Linked Immuno Sorbent Assay tests (NovaLisa, NovaTec). The samples were collected from Kurdistan Teaching Center for Gastroenterology & Hepatology and Ali Kamal Consultation Clinic in Sulaimani city form December 2012 to March 2014. ABO Blood groups were determined using standardized hemagglutination methods.
Results: About 48% of the patients complained of dyspepsia between 1 to 5 years. A significant correlation was found between duration of dyspepsia and the titer of anti H. pylori IgG. The maximum level was found among patients with longer duration (5-15years) of dyspepsia. The most common presentation was epigastric pain (78%) followed by decreasing appetite (39%) and GI bleeding (26%). The most common OGD finding in patients was antral gastritis (59%) followed by duodenal ulcer (21%). Most of the patients had either blood group O (44%) or A (30%) than controls (17.3%, 20%). There was statistically significant (p<0.01), OR = 3.5 (1.3 – 5.2) relation between blood group and H. pylori infection. The majority (70%) of patients had positive family history of dyspepsia than controls (17.3%), with OR=10.5 (2.9 – 37.3). There was significant relation between crowding index and H. pylori infection. The mean crowding index among patients and controls were (4.4 ± 2.3), (2.1 ± 0.9) respectively, with OR= 3.0 (1.9 - 4.9). No significant difference was found between patients and control group regarding age, gender, and marital status. Conclusions: We realized that there was significant association between H. pylori infection and family history of dyspepsia, crowding index and ABO blood group.


Key Words:  Dyspepsia, H. pylori, blood group, family history, crowding index, KCGH, Sulaimani.


References

[1] Tack J, Bisschops R, Sarnelli G."Pathophysiology and treatment of functional dyspepsia", Gastroenterology. Vol. 127, pp 1239-1255.(2004).

[2] Talley NJ, Vakil N. "Guidelines for the management of dyspepsia", Am. J. Gastroenterol. Vol. 100 No. 10, pp 2324–2337.(2005).

[3] Longo DL, Kasper DL, Jameson JL,Fauci AS, Hauser SL, Loscalso J"Atherosclerosis. In: Harrison's principles of internal medicine".18thEd.The McGraw-Hill Companies, Inc. pp 2513–2530, pp 3211-3225. (2012).

[4] Kivi M, Tindberg Y. "Helicobacter pylori occurrence and transmission: A family affair", Scand. J Infect Dis. Vol.38, pp 407-417. (2006).

[5] Ables AZ, Simon I, Melton E. "Update on Helicobacter pylori Treatment", Am Fam Physician.Vol. 75, pp 351-358. (2007).

[6] Martins LC, de Oliveira Corvelo TC, Oti HT, et al "ABH and Lewis antigen distributions in blood, saliva and gastric mucosa and H pylori infection in gastric ulcer patients", World J Gastroenterol. Vol. 12, pp 1120-1124. (2006).

[7] Wu TC, Chen LK, Hwang SJ, "Seroprevalence of Helicobacter pylori in school-aged Chinese in Taipei City and relationship between ABO blood groups", World J.Gastroenterol. Vol. 9, pp 1752-1725. (2003).

[8] Melki IS, Beydoun HA, Khogali M, Tamim H, Yunis KA. "National Collaborative Perinatal Neonatal Network (NCPNN)", Household crowding index: a correlate of socioeconomic status and inter-pregnancy spacing in an urban setting J Epidemiol Community Health. Vol. 58, No. 6, pp 476-480. (2004).

[9] Ayoub MA. "Frequency of Helicobacter Pylori Infection", Among Dyspeptic Patients in Mosul University of Mosul Phd thesis. (2009).

[10] Cizginer S, Ordulu Z, Kadayifci A. "Approach to Helicobacter pylori infection in geriatric population", World J Gastrointest PharmacolTher. Vol. 65m No.3, pp139-147. (2014).

[11] Kindt S, Tertychnyy A, de Hertogh G, Geboes K, Tack J. "Intestinal immune activation in presumed post-infectious functional dyspepsia", Neurogastroenterol Motil. Vol. 21, No. 8, pp 832-856. (2009).

[12] Marshall JK, Thabane M, Garg AX, Clark WF, Moayyedi P, Collins SM. "Walkerton Health Study Investigators. Eight year prognosis of post infectious irritable bowel syndrome following waterborne bacte­rial dysentery", Gut. Vol. 59, No. 5, pp 605–611. (2010).

[13] Drumm B, Koletzko S, Oderda G. "Helicobacter pylori infection in children: a consensus statement", Medical Position Paper: A report of the European Pediatric Task Force on Helicobacter pylori on a consensus conference. Budapest, Hungary, September 1998. J Pediatr Gastroenterol Nutr. Vol. 30, pp 207-213. (2003).

[14] Abbas E. "Serological and histopathological study of Helicobacter pylori infected patients", MSc Thesis, Al-Kufa University. (2005).

[15]Shuker WS. "Immune response in patients infected with Helicobacter pylori, Entamoebahistolytica and Giardia lamblia", PhD.Thesis. University of Baghdad. (2007).

[16] Alsaimary I,Al-Sadoon M, Jassim A,Hamadi S. "Clinical Findings and Prevalence of Helicobacter Pylori in Patients with Gastritis B in Al-Basrah Governorate", OMJ. Vol. 24, pp 208-211. (2009).

[17] Nkrumah KN. "Endoscopic evaluation of upper abdominal symptoms in adult patients", Saudi Aramco-Ai Hasa Health Center, Saudi Arabia. West African Journal of Medicine. Vol. 21, No.1, pp 1-4. (2002).

[18] Agbakwuru EA, Fatusi AO, Ndububa DA,Alatise OI, Arigbabu OA, Akinola DO. "Pattern and validity of clinical diagnosis of upper gastrointestinal diseases in south-west Nigeria", Afr Health Sci. Vol.6, No.2, pp 98-103. (2006).

[19] Abood RA. "Evaluation of Endoscopy Based Methods (Histopathology, Brush cytology, and Urease test) For The Detection of Helicobacter pylori PhD". Thesis. University of Basrah. (2007).

[20] Baban FA and Mohammed OM. "The Prevalence of Helicobacter pylori In Upper Gastrointestinal Disorders", (JZS). Part A, Vol. 6, No. l, pp l-8. (2003).

[21] Jeje E, Olajide T, Akande B. "Upper Gastrointestinal Endoscopy - Our Findings, Our Experience in Lagoon Hospital", Lagos, Nigeria. Macedonian Journal of Medical Sciences. 1, Vol. 6, No.2, pp 168-173. (2013).

[22] Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T et al. "Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development", World J Gastroenterol. 14; Vol. 20, No.18, pp 5461-5473. (2014).

[23] Dixon M F, Genta R M, Yardley J H , Correa P. "Classification and grading of gastritis", The updated Sydney system. Am J Surg pathology. Vol. 20, No.10, pp 1161- 1181. (1996).

[24] Dixon M. "Pathology of Gastritis and Peptic Ulceration", In Helicobacter pylori: Physiology and Genetics, edited by Mobley H LT, Mendz G L. &Hazell S L, Washington, DC: ASM press. pp 459-469. (2001).

[25] Atherton J. "The Pathogenesis of Helicobacter pylori Induced Gastro-Duodenal Diseases. Annual Review of Pathology", Mechanisms of Disease. Vol.1 pp 63-96. (2006).

[26] Yamada T, Alpers DH, Kalloo AN, Kaplowitz N, OwyangCh, Powell DW. "Helicobacter pylori In: Textbook of Gastroenterology", 5th edition, Blackwell Publishing, Singapore. pp 925-1013. (2009).

[27] Malcolm CA, MacKay WG, Shepherd A, Weaver LT. "Helicobacter pylori in children is strongly associated with poverty", Scott Med J. Vol. 49, pp 136-138. (2004).

[28] McCallion WA, Murray LJ, Bailie AG, Dalzell AM, O'Reilly DP, Bamford KB.,"Helicobacter pylori infection in children: relation with current household living conditions", Gut. Vol. 39, pp18-21. (1996).

[29] Torres J, Leal-Herrera Y, Perez-Perez G, Gomez A, Camorlinga-Ponce M, Cedillo-Rivera R, et al. "A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico", J Infect Dis. Vol. 178, pp 1089-1094. (1998).

[30] Moayyed P, Axon AT, Feltbower R, Duffett S, Crocombe W, Braunholtz D, et al."Relation of adult lifestyle and socioeconomic factors to the prevalence of Helicobacter pylori infection", Int J Epidemiol. Vol. 31, pp 624-631. (2002).

[31] Bastos J, Peleteiro B, Pinto H, Marinho A, GuimaraesJT,Ramos E, et al. "Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)", Digestive and Liver Disease, Vol. 45, pp 290– 295. (2013).

[32] Ford AC, Forman D, Bailey AG, Goodman KJ, Axon AT, Moayyedi P. "Effect of sibling number in the household and birth order on prevalence of Helicobacter pylori: a cross-sectional study", International Journal of Epidemiology, Vol. 36, pp 1327–1333. (2007).

[33] Gao L, Weck MN, Raum E, Stegmaier C, Rothenbacher D, Brenner H. "Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany", International Journal of Epidemiology, Vol. 39, pp 129–134. (2009).

[34] Minocha A, Wiginigton W, and Johnson W. "Detail Characterization of Epidemiology of Uninvestigated Dyspepsia and its Impact on Quality of Life among African American as Compared to Caucaians", Am J Gastroenterol. Vol. 101, pp 340. (2006).

[35] Mussa YM, Mohammad MO, Abdulsahib SH. "Quality of Life among Adult Patients with Peptic Ulcer in the City of Sulaimani", National for Nursing J Specialties. Vol. 24, No.1, pp 81-85. (2011).

[36] Kanbay M, Gur G, Arslan H, Yilmaz U, Boyacioglu S, "The relationship of ABO blood group, age, gender, smoking, and Helicobacter pylori infection", Dig Dis Sci, Vol. 50, pp 1214-1217. (2005).

[37] Valliani A, Khan F, Chagani B, Khuwaja A, et al "Factors Associated with Helicobacter Pylori Infection, Results from a Developing Country Pakistan", Asian Pacific J Cancer Prev, Vol. 14, No.1, pp 53-56. (2013).

[38] Jaff MS. "Relation between ABO blood groups and Helicobacter pylori infection in symptomatic patients", Clin Exp Gastroenterol. Vol. 4, pp 221-226. (2011).

[39] Boren T, Falk A , Roth K, Larson G, Normark S. "Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens", Science Vol. 262, pp 1892–1895. (1993).

[40] Alkout AM, Blackwell CC, Weir DM. "Increased inflammatory responses of persons of blood groups O to Helicobacter pylori", J Infect Dis. Vol. 181, pp 1364-1369. (2000).