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jzs-10628


Acute toxicity of Pistacia atlantica green seeds on Sprague- Dawley rat model

Hiewa Othman Dyary1, Heshu Sulaiman Rahman123, Hemn Hassan Othman123, Snur Mohammad1, Amen Hassan, Rasedee Abdullah3

1 College of Veterinary Medicine, University of Sulaimani, Sulaimani Nwe, Street 27, Sulaimani City, Iraq
2 Department of Medical Laboratory Science, College of Health Science, Komar University of Science and Technology, Sarchinar
District, Sulaimani city, Iraq
3 Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia


Abstarct

The acute toxic effect of the aqueous extract of Pistacia atlantica green seeds was investigated in groups of Sprague-Dawley rats at oral doses of 200, 400, and 800 mg/kg body weight. After 14 days, there was no significant difference (p>0.05) in behavior, food and water consumption, body weight gain, and hematological and serum biochemical parameters between untreated control and extract-treated rats. There were lesions in the liver and kidney indicating that aqueous P. atlantica seed extract causes some hepatoxicity and nephrotoxicity in rats.

KeywordsPistacia atlantica, Acute toxicity, Animal model, Mount Atlas mastic tree



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