Thermostable alkaline phosphatase in bacteria and archaea at a glance
Haider Mousa Hamzah1
Department of Biology, College of Science, University of Sulaimani, Sulaymaniyah, Kurdistan Region, Iraq

Original: 20 June 2019, Revised: 4 August 2019, Accepted11 September 2019Published online20 December 2019


Abstract

Alkaline Phosphatase (AP) is one of the most ubiquitous enzymes for the dephosphorylation of nucleic acids in molecular biology; as reporter enzymes for secreted proteins; for
colorimetric immunoassays; and as an indicator of activity in research and diagnostic kits. Today, there are continuing efforts suggesting the possibility of producing unique AP from
thermophilic bacteria and archaeal cells. As AP is found in a few members of thermophiles, it is also anticipated that it will be detected in their siblings, yet the reason behind the
variation in their AP activities is ambiguous. This mini review provides a comprehensive survey of the bacterial and archaeal alkaline phosphatases with particular emphasis on the
thermostable APs from the members of thermophiles and their activity variation. 

Key Words:Alkaline phosphatase, Archaea, Hyperthermophile, Thermophiles

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