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jzs-10835

Obesity Parameters in Polycystic Ovary Syndrome in Duhok City
Suzan Omer Rasool 1*

1 Department of Clinical Pharmacy, College of Pharmacy, University of Duhok, Duhok, Kurdistan Region, Iraq

*Corresponding author’s e-mail: suzan.rasool@uod.ac

Original: 10 August 2020   Revised: 28 October 2020  Accepted: 29 November 2020  Published online: 20 June 2021  

DOI link:


Abstract

Background: PCOS is linked to obesity, increased risk of metabolic syndrome, and cardiovascular adverse manifestations.  About 30-75% of women with PCOS are obese.  Aim of the study: This study aimed to estimate the obesity parameters in PCOS and compare these results to women without PCOSMethods: In this cross-sectional study, the BMI and Waist/Hip ratio of 150 women with established PCOS according to the diagnostic criteria were compared to 100 age-matched healthy womenResults: 95 patients and 50 of the comparison group were obese. The difference in the mean of BMI in PCOS patients and the comparison group was statistically highly significant (P < 0.001). The Waist/Hip ratio was above 0.85 in 91 patients and 73 healthy individuals and statistically, the difference was not significant when a cut-off point of 0.85 is considered (P > 0.05 unpaired T-test)Conclusions: BMI was found to be a more sensitive parameter than Waist/Hip ratio, in the determination of obesity-associated with PCO.

Key Words: Obesity, PCOS, BMI, W/H.


References

[1] Amato M.C., Gall Uzzo A., Finocchiaro S., et al. "The evaluation of metabolic parameters and insulin sensitivity for a more robust diagnosis of the polycystic ovary syndrome". Clinical Endocrinology (Oxf). Vol 69, pp. 52-60. (2008).

[2] Lerchbaum E., Gruber H.J., Schwetz V., et al. "Fatty liver index in polycystic ovary syndrome". European Journal of Endocrinology. Vol 165, pp. 935-943. (2011).

  [3] Orlik B., Madej P., Owczarek A., et al. "Plasma omentin and adiponectin levels as markers of adipose tissue dysfunction in normal weight and obese women with polycystic ovary syndrome". Clinical Endocrinology (Oxf). Vol 81, pp. 529-535. (2014).

[4] Diamanti K. E. "Polycystic ovarian syndrome pathophysiology molecular aspects and clinical implications". Expert Rev Mol Med. Vol 10, e3. (2008).

[5] Lim S.S., Norman R.J., Davies M.J., et al. "The effect of obesity on polycystic ovary syndrome a systematic review and met-analysis". Obesity Reviews. Vol 14, pp. 95–109. (2013).

[6] Ehrmann D.A. "Polycystic ovary syndrome". N Eng. J Med. Vol 352, pp. 1223–6. (2005). 

[7] Essah P.A., Nestler J.E. "The metabolic syndrome in polycystic ovary syndrome”. Journal of Endocrinological Investigation. Vol 29, pp. 270–80. (2006). 

[8] Borruel S., Moltó J.F., Alpañés M, et al. "Surrogate markers of visceral adiposity in young adults waist circumference and body mass index are more accurate than waist-hip ratio model of adipose distribution and visceral adiposity index". PloS One. Vol 912, e114112. (2014).

[9] Zeng Q., He Y., Dong S., et al. "Optimal cut-off values of BMI waist circumference and waist: height ratio for defining obesity in Chinese adults”. British Journal of Nutrition. Vol 112, No. 10, pp. 1735-44. (2014).

[10] Haslett C., Chilver's E., Boon N., et al. "Davidson'sprinciples & practice of medicine". 19th ed. London, Churchil Livingstone, (2002).

[11] Balen A.H., Laven J.S., Tan S.L., et al. "Ultrasound assessment of the polycystic ovary: international consensus definitions". Hum Reproduction Update. Vol 9, No. 6, pp. 505–14. (2003).

[12] World Health Organization. "Waist circumference and waist-hip ratio: report of a WHO expert consultation". Geneva, (2008).

[13] Yildiz, B.O., Knochenhauer, E.S. and Azziz, R. "Impact of obesity on the risk for polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism. Vol 93, No. 1, pp. 162-168. (2008).

[14] Vilmann, L.S., Thisted, E., Baker, J.L., et al. "Development of obesity and polycystic ovary syndrome in adolescents". Hormone Research in Pediatrics. Vol 78, No. 5-6, pp. 269-278. (2012).

[15] Lu, D.F. and Guo, X.H. "Parameters of obesity in polycystic ovary syndrome". Journal of Rare Diseases Research & Treatment. Vol 2, No. 1, pp. 19-22. (2016).

[16] Sam, S. "Obesity and polycystic ovary syndrome". Obesity Management. Vol 3, No. 2, pp. 69-73. (2007).

[17] Mandrelle, K., Kamath, M.S., Bondu, D.J., et al. "Prevalence of metabolic syndrome in women with polycystic ovary syndrome attending an infertility clinic in a tertiary care hospital in south India". Journal of Human Reproductive Sciences. Vol. 5, No. 1, pp. 26. (2012).

[18] Al-Bayatti, A.A. "Insulin resistance and upper-body obesity in polycystic ovary syndrome". Middle East Fertility Society Journal. Vol 11, No. 3, pp. 202. (2006).

[19] Milnerowicz, H. and Madej, P. "The effect of abdominal obesity in patients with polycystic ovary syndrome on metabolic parameters". European Review for Medical and Pharmacological Sciences. Vol 21, pp. 4755-4761. (2017).