Study Hypoglycemic activity of the Rhizomes of Rheum ribes (Rhubarb) in Normal and Alloxan Diabetic Rabbits

Dlawar M. Sabir

College of Science, Salahaddin University


Blood glucose levels of the normal and alloxan- diabetic male albino rabbits were determined after oral administration of various doses of powdered Rheum ribes rhizomes (Very bitter). It was considered as an effective anti diabetic agent for many decades. In normal rabbit 2gm/kg dose caused decrease in blood glucose. Tie effect was maximum at a 12 hours intervals, after which it was gradually-decreased. The 4 and 6 gm/kg doses also lowered the level of blood glucose of these rabbits. In diabetic rabbit the 2gm/kg dose did not cause a significant decreased in blood glucose. However 4 and 6 gm/kg
doses produced a dose dependent decreases in blood glucose levels .Up to date, 1999 reviews of literature showed no new works in this field.

l. Hoffmann D., new Herbal, 2nd Ed,.,Element, 1997,22g.
2- Butt T.A. The hypoglycemic response to glucagons in normal and alloxandiabetic rabbits,
M.Phip. Thesis, uni. Of Karachi,1962,p57.
3. Fings C.S., Tatliff C.R., Dunn R.T., Toro, C., Ackerman p.G. Clinical
Chemisty, Little Browning and Company, Boston, 1970, p115.
4. Snedecor G.W., Cochran, W.G., Statistical Methods 6th Ed. Ames, Iowa state university
Press 1967.
5. Akhtar M.S., Athar M.A., Yaqub M., Planta Med. 1981,42,205.
6. Akhtar V.0., Adanlowo T.A., Olaniyi A.A., Planta Med.1977,31,367.
7. Shani J.A., Goldschemied, A., Joseph B., Alrouson 2., Sulman E.G., Arch.Int. Pharmacodyn.
8. Goth M.D., Medical Pharmacology 7thEd. C.V. Mosby Company, Saint Louis ,1974,472.
9. Guyton, M.D., Text Book of Medical Physiology, 5th Ed. Philadelphia, W.B Saunders
Company, 1976.