Synthesis and Characterization of Novel Biological Mixed Organometallic Chromium (III) Complex of Potential Allyl-Sulfur Compounds of Garlic, Allicin

Authors

  • M. A. Andullah College of Science, University of Sulaimani, Kurdistan Region, Iraq. Author
  • D. I. Tofiq College of Science, University of Sulaimani, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10085

Keywords:

Chromium (III), Organometallic, Garlic, Allicin

Abstract

From the readily acid and base hydrolysis (pH - dependence) of loosely Cr - S bond of bis (L- cysteinato)chromium (III) complexes, a biological mixed organometallic - werner chromium complex, of trans - bis [(n3) s - allyl mercapto cysteinato ] chromium (III) hydroxide, has been synthesized via intermolecular insertion reaction of allyl sulfenic acid, which was extracted and isolated from natural garlic. This complex was characterized using IR, NMR, UV -Visible spectroscopic techniques and elemental analysis. Also biological activity of the prepared cormplex was tested in vitro.

References

E.Dorant,Van den, P.A. Brandtt., R.A .Goldbohm, R.J. Hermns and F. Stunnan "Garlic and its significance for the prevention of cancer in humans", acritcal

view, Br. J. cancer,1993,67 (3),424 -9 . DOI: https://doi.org/10.1038/bjc.1993.82

D.B. Foushee, J. Ruffin, U. Banerjee "Garlic potential role in reducing heart disease", Br. J .Clin .Proct . 1993, 47(2),64-5. DOI: https://doi.org/10.1111/j.1742-1241.1993.tb10392.x

C. Legnani, M. Frascaro, G. Guazzaloca,S. Ludovici , G.Cesarano and S. Cocche

"Thioally compound potent inhibitors of cell proliferation" ,Biochim Biophys Acta, 1994,1221(1),73-7. DOI: https://doi.org/10.1016/0167-4889(94)90218-6

(a) S. Sutabhaha, M.Suttajitm, "Antitumor effects of organosulfur compounds present in garlic against canine mammary tumor cell", FASEBJ, 1992, 6(4), I391.

(b) S.G. Sundaram,J.A. Milner "Impact of organosulfur compounds in garlic on canine marnmary tumor cells in crtlture",cancer lett.1993 ,74(1-2), 85-90. DOI: https://doi.org/10.1016/0304-3835(93)90048-E

Great Bear Communications, Inc. at Intoegreat bear, (net Copy right), 1996, 1997 sect 1, Volum 2."Garlic Allium Sativuum family": Liliaceae.

Herbal information center, "Gralic" Herbs Seite 1998 1.Von 3, Seit 3, Von 3.

"A clove of Garlic or Health and Cookery, Recipes and Traditions, Garlic Natures" Super Healer by Joan wilen and LydiaWilen ;1996.

R.Gebhardt *Inhibition of Cholesterol Biosynthsis by Water- Soluble Garlic extracts",Drug Re s .1992,41,1800-804

The Nutration Reporter "The Wander of Garlic" 1996, Seite 2,von.A.

F.Freeman, Y.Kodera "Garlic Chemistry; Stability of allicin in blood, solvents and simulated physiological fluds", J. Agri and Food Chemistry; 1995,43,2332- 2338. DOI: https://doi.org/10.1021/jf00057a004

(a) E. Block "The Organo Sulfur Chemistry of the Genus Allium -Implications for organic chemistry of sulfur", Angew chem. Int. Ed. Eng1, 1992, 31, 1135- 1178. DOI: https://doi.org/10.1002/anie.199211351

(b) E.Block "The chemistry of garlic and onion", Scientific American, 1985, 252, 114-119. DOI: https://doi.org/10.1038/scientificamerican0685-114

(c) E.Bloc( S.Ahmad, J.L.Catatfamo, M.Kjain and R.A.Castro. "Anti thrombotic Orgaosulfur compounds from garlis", J.Am. Chem. Sco. 1986, 108_,7045. DOI: https://doi.org/10.1021/ja00282a033

T.H Yu and C.M Wu "Stability of allicin in garlic Juice" , J.Food Sci ,1989, 54,977-981 DOI: https://doi.org/10.1111/j.1365-2621.1989.tb07926.x

Kyollic information.Volum (1)and Volum (2) of Kyolic Scientific information, seite 3 Von3 and seite 4_Yon 5 1997.

S.Nakagawa, Masamoto, K.Sumiyson "Effect of Raw garlic extract on groMh of young rats and their oranges after petraral administrati on" , J.Toxical ,Sc. 1980, 5,91-112 DOI: https://doi.org/10.2131/jts.5.91

J.A. Lyborser, J.S Gallagher, D.W Pulver "Occupational Asthma lnduced by Inhalation and Ingestion of garlic", J.Allerg Clin. Immrmol,1982 69,448. DOI: https://doi.org/10.1016/0091-6749(82)90120-8

L. Lawson, D.K Ransom and Hughes "Inhibition of Whole Blood plateletet Aggregation by compound in garlic" ,Thrombosis research,l992,65 ,141-156. DOI: https://doi.org/10.1016/0049-3848(92)90234-2

(a) H.Joam, L.Lawson, Grace Han "A spectrophotometric Method for Quantitative Determination of Allicin and Total Garlic Thiosulfinates",,A,nalytical Biochemisny

Chem J;Super criteal,1995.

(b) "Fluid Chromatography of garlic extracts with mass spectrometric identification of allicin", J Chromatogr. Sci.l994, 23(3), 248-400.

(a) A. Stoll, E.Seebeck "Chemical investigation of allicin, the specific principle of garlic", Ad.Enzymol, 1951,11,377 -400. DOI: https://doi.org/10.1002/9780470122563.ch8

(b) P.R.Mayeux, K.c. Agrawal, J.SH. Tou, B.T.King, G.L.Lipton, A.L.Hyman, D.B. M.Namara "T!e pliarmacological effects of allicin , a constituent of garlic"j Agents and

Actions, 1988, 25,182-190 DOI: https://doi.org/10.3817/1288078182

APIC USA,Inc. Amino Acids, Herbs, A primer on the chemistry of Garlic (1998) and Herb Glossaries,1997, Action, 1988, 25, 201 -209.

R. Aharon M. Talia, K.Leonid, w.Meir, M.David and levweiner,,The mode cf Action of Allicin Trapping of radicals and interaction with thiol containing

proteins", J. B iochemica B iophys ic a Acta,I998,1379, 233 -244.

(a) P.OBrien, J.P. Jesus and T.M.Santo " A kinetic and equilibrium study of the reaction of postassium and sodium bis L- cysteinato (N,O,S) - (chromium) (III); in

moderately acidic solution", Inorg. Chem. Acta l987, 131; 5 _ 7 .

(b) M.A. Abdullah and B.H. Abdullah "Kinetic studies of the ring closur reaction of

sodium bis (L- cysteinato chromate (III) in nutral aqueous solution-", Iraqi J. of chem,

,24, (2),233.

E.O. Fisher and H .Branner, Chem. Ber 1956,98,175.

R.P.A. Sneeden, "organochromium compounds" academics press a subsidiary of Harcourt Brace, Jouanovanovich, publisher 1975, ch.2,97 . DOI: https://doi.org/10.1016/B978-0-12-653850-2.50006-X

P. Powll. "Principle of organometallic chemistry" Ch.8. 253, 1998.

M.A.Abdullah, manuscript submitted for publication "synthesis and characterization of new class of mixed polysufide ligand with chromium (III) complexes" 2000.

(a) M.E. Dion, M. Ager, ,JA Milner, "S-ally1 Cystein inhibits nitrosomorpholin formation and bioactivation", Nutr. Cancer, 1997,28(1), 1_6. DOI: https://doi.org/10.1080/01635589709514545

(b) J.T. Pinto, C.Qiao, J, Xing, R.S. Rivlin, M.L.protomastro., M.L.weissler, X. Tao, H.Thaler and W.D. Heston "Effect of garlic thioallyl derivatives on growth, glutathione

concentration and polyamine formation of human prostate carcinoma cellJin cuffur" HmJ.clin.Nutr. 1997, 66(2), 398-405. DOI: https://doi.org/10.1093/ajcn/66.2.398

J. Barrett and P.O Brienl and J.D. Pedrosa. "chromium (III) and Glucose Tolerance Factor", polyhedron, 1985, 4(1), 1- 14. DOI: https://doi.org/10.1016/S0277-5387(00)84214-X

(a) David Hoffman, MN.I.M.H "arlic" (1995), (b) M.T. Tradfer, M.A.Ali, N.Saravanan, W.Y. Weng, S.Kumar, "coordination

Chemistry and biological activity of two tridentate ONS and NNS shiff bases", Transition Metal Chemistry, 2000, 25 (3), 295. [29] F.G.R. Gimbiett " Inorganic polymer chemistry" P.219 - 230 and 399 - 411,1963.

P. de Meester, D.J.Hodgson, F.C. Freeman and C.J. Moore, "Tridentate Coordination by the L-Cystein Dianion,Crystal and Molecular structure of sodium

Bis (L-Cysteinato) chromate (III) dihydrate", Inorg. chem. 1977,16,1494. DOI: https://doi.org/10.1021/ic50172a051

T.L. AIIen, " Spectrophotometer Chromium Determinati on, Analytical Chemistry", 1958, 30,(3),447-449. DOI: https://doi.org/10.1021/ac60135a039

K. NaKamato,Infrared and Raman spectra of Inorganic compounds; John Wiely and Sons;New york 3rd. ed 1977,305.

Published

2001-05-17

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How to Cite

Synthesis and Characterization of Novel Biological Mixed Organometallic Chromium (III) Complex of Potential Allyl-Sulfur Compounds of Garlic, Allicin. (2001). Journal of Zankoy Sulaimani - Part A, 5(1), 11-26. https://doi.org/10.17656/jzs.10085

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