Identification and Molecular Characterization of B-Tubulin Gene from Dermatophyte Pathogen Microsporum Canis

Authors

  • Aumaid U. Uthman Department of Dermatology, Vienna Medical University and College of Veterinary Medicine, University of Sulaimani, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10157

Keywords:

Microsporum canis, Dermatophytes, β-tubulin, Gene expression

Abstract

Microsporum canis is the most common pathogen causing dermatophytosis in dogs and cats, which can transmit the pathogen to humans. The disease is increasing in many European countries. Studies regarding the structure, expression, and organization of M. canis genes have been relatively limited because of it's non-aggressive and non-life threatening nature. Microtubules are essential cytoskeleton polymers in all eukaryotes. They are made of α and β-tubulin heterodimers. In this study the DNA and the structural organization of β-tubulin gene of M. canis is described. The DNA of 2487 bp has been identified and sequenced. The ORF of 1341 bp encoding a protein of 447 amino acids with a molecular weight of 49.8 kD is interrupted by eight introns (56-187bp). The gene is highly homologous to β-tubuli of Trichophyton rubrum (%98) and A spergillus parasticus (%91). This data may form one of the bases for the development of molecular investigation of dermatophyte fungi M. canis.

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Published

2007-02-06

How to Cite

Identification and Molecular Characterization of B-Tubulin Gene from Dermatophyte Pathogen Microsporum Canis. (2007). Journal of Zankoy Sulaimani - Part A, 10(1), 1-8. https://doi.org/10.17656/jzs.10157

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