Flow- Injection Spectrophotometric Determination of some Sulpha Drugs via Oxidative Coupling with 4-Amino-N, N-diethylaniline. Application to Various Samples

Authors

  • Yousif J. Azeez College of Science, Salahaddin University, Erbil, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10196

Keywords:

Spectrophotometric, Sulpha Drugs, Oxidative Coupling, 4-Amino-N, N-diethylaniline

Abstract

A flow injection spectrophotometric method is described for the determinaiton of sulphonamides in aqueous and biological samples. The method is based on the oxidative coupling reaction of 4-amino-N, N-diethylaniline with sulphonamide drugs in the presence of potassium dichromate as oxidizing agent. Intense violet, water soluble dye was obtained which has a maximum absorption at 550nm,. Linear calibration graphs were obtained for different sulphonamides with a molar absorpitivity of 4200-5270 l mol-1 cm-1 and a relative standard deviation less than 0.56%. The proposed method has proved to be highly sensitive (detection limit range 0.30-0.63 μg ml-1  sulphonamide) and accurate (recovery % was 98.2-101.2%). The nature of the coloured dye and its stability constant were determined. The method was applied successfully to the determination of sulphonamide drugs in pharmaceutical preparations, blood and urine samples.Keywords: FIA, Spectrophotometer 4-amino-N, N-diethylaniline

References

Stewart B. W. and Kleihues P. World Cancer Report. IARCPress. 2003, Lyon.

Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994; 266 (5182): 66-71. DOI: https://doi.org/10.1126/science.7545954

Chlebowski RT, Hendrix SL, Langer RD, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. JAMA. 2003; 289: 3243-3253. DOI: https://doi.org/10.1001/jama.289.24.3243

Gail MH, Brinton LA, Byar DP, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. Journal of the National Cancer Institute. 1989; 81(24): 1879-1886. DOI: https://doi.org/10.1093/jnci/81.24.1879

Fisher B, Osborne CK, Margolese R, et al. Neoplasms of the breast. In: Holland JF, Frei E, Bast RC, et al., Eds.: Cancer Medicine. Philadelphia: Lea & Febiger, 3rd ed., 1993:1706-1716.

McDivitt RW. Breast. In: Kissane JM: Anderson's pathology, ninth edition. C.V. Mosby Company, St. Louis, Missouri. 1990; 344-369.

Kolb E. Comparison of the Performance of Screening Mammography, Physical exam. and Breast US in Detection of Breast Cancer. Radiology, 2000: 165-175. DOI: https://doi.org/10.1148/radiol.2251011667

Ferlay J, Bray F, Pisani P, et al. Cancer Incidence, Mortality and Prevalence Worldwide. IARC Cancer Base No. 5, 2004: version 2.0. IARC Press, Lyon.

Henderson BE, Ross R, Bernstein L. Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res. 1988; 48:246–253.

James T B, Margaret M K, Kevin M G. Occupation and breast cancer: a Canadian case-control study. Ann. N. Y. Acad. Sci. 2006; 1076: 765-777. DOI: https://doi.org/10.1196/annals.1371.019

Nicholas P, Julia S. Presentation: Radiological Society of North America annual meeting, Chicago. 2007; Nov. 26.

Albreksten G, Heuch I, Kvale G. The short and long term effect of a pregnancy on breast cancer risk: a prospective study of 802,457 parous Norwegian women. Br. J. Cancer. 1995; 72:480-4. DOI: https://doi.org/10.1038/bjc.1995.359

Mandana E, Mariam V, Ali M. Risk factors for breast cancer in Iran: a casecontrol study. Breast Cancer Res.2002; 4(5): R10. DOI: https://doi.org/10.1186/bcr454

Ambrosone CB, Kropp S, Yang J, et al. Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2008; 17(1):15-26. DOI: https://doi.org/10.1158/1055-9965.EPI-07-0598

Kathleen C. Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years. Breast Cancer Res. Treat. 2007; 120(1): 1825.

Perkins CI, Morris CR, Wright WE, Young JL. Cancer Incidence and Mortality in California by Detailed Race/Ethnicity, 1988-1992. Sacramento, CA: California Department of Health Services, Cancer Surveillance Section, 1995.

Harirchi I, Ebrahimi M, Zamani N, et al. Breast cancer in Iran: a review of 903 case records. Public Health. Iranian Center for Breast Cancer (ICBC), Tehran, Iran. 2000; 114 (2):143-5. DOI: https://doi.org/10.1016/S0033-3506(00)00324-3

Perkins CI, Hotes J, Kohler BA, Howe HL. Association between breast cancer laterality and tumor location, United States, 1994-1998. Cancer Causes Control. 2004; 15(7):637-45. DOI: https://doi.org/10.1023/B:CACO.0000036171.44162.5f

Blair, Hansen Am., et al. Chemical exposure in the workplace associated with some evidence of a higher breast cancer risk. Int. J. Epidemiol. 1999; Volume 36, p.43-7. DOI: https://doi.org/10.1002/(SICI)1097-0274(199907)36:1<43::AID-AJIM6>3.0.CO;2-A

Furberg AS, Veierød MB, Wilsgaard T, et al. Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk. J Natl Cancer Inst. 2004; 96 (15):1152-60. DOI: https://doi.org/10.1093/jnci/djh216

Furberg AS, Thune I. Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. Int J Cancer. 2003; 10, 104 (6):799. DOI: https://doi.org/10.1002/ijc.10974

Published

2008-11-05

How to Cite

Flow- Injection Spectrophotometric Determination of some Sulpha Drugs via Oxidative Coupling with 4-Amino-N, N-diethylaniline. Application to Various Samples. (2008). Journal of Zankoy Sulaimani - Part A, 12(1), 67-76. https://doi.org/10.17656/jzs.10196

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