Synthesis and Characterization of some new 2,5-disubstituted- 1,3,4-oxadiazole derivatives Containing Antipyrine moiety.

Authors

  • Mohammad Amin Mohammad Rashid Faculty of Science and Science Education, School of Science, Department of Chemistry, University of Sulaimani, Kurdistan Region, Iraq. Author
  • Sewara Jalal Mohammed Mohammed Faculty of Science and Science Education, School of Science, Department of Chemistry, University of Sulaimani, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10501

Keywords:

4-Aminoantipyrine, Ethyl acetoacetate, Enaminone, Hydrazide, Oxadiazole derivatives

Abstract

Some new 2,5-disubstituted-1,3,4-oxadiazolels of type (E)-4-((1-(5-(substitutedphenyl) 1,3,4-oxadiazol-2-yl)pro-1-en-2-yl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)- one were synthesized in (60-81%) yield under solvent free conditions using grinding technique through the reaction of hydrazide intermediate with benzaldehyde or different substituted benzaldehydes in the presence of catalytic amounts of iodine molecular as a single step. The structures of all the synthesized compounds were confirmed on the basis of their physical properties, IR, 1H-NMR and Mass spectral data.

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Published

2016-06-20

How to Cite

Synthesis and Characterization of some new 2,5-disubstituted- 1,3,4-oxadiazole derivatives Containing Antipyrine moiety. (2016). Journal of Zankoy Sulaimani - Part A, 18(2), 11-26. https://doi.org/10.17656/jzs.10501