Assessment on Elevated Serum Vitamin B 12 Level in Cancer Patients at Hiwa Hospital

Authors

  • Niann Noori Department of Chemistry, School of Science Education, Faculty of Science and Science Education, University of Sulaimani, Kurdistan Region, Iraq. Author
  • Zhian S. Ramzi Department of Biochemistry, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Kurdistan Region, Iraq. Author
  • Aveen H. Saeed Department of Hematology, Hiwa Hematology, Oncology Center, Sulaimani, Kurdistan Region, Iraq. Author
  • Kosar A. Omer Department of Health, Kurdistan Institution for Strategic Studies and Scientific Research, Sulaimani, Kurdistan Region, Iraq. Author
  • Dosti N. Othman Department of Health, Kurdistan Institution for Strategic Studies and Scientific Research, Sulaimani, Kurdistan Region, Iraq. Author
  • Beston F. Nore Department of Hematology, Hiwa Hematology, Oncology Center, Sulaimani, Kurdistan Region, Iraq. & Department of Chemistry, University of Sulaimani, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10539

Keywords:

Cobalamin, Leukemia, Biomarker, Solid Cancer, Circulating Vitamin B12

Abstract

Free circulating serum Vitamin B12 (Vit-B12) levels is mainly used for diagnosis the deficiency of cobalamin (Cbl). However, approximately 15% of patients have hypercobalaminemia (high Vit-B12 levels) without any existing consensus for its clinical implications.But elevated levels of serum Vit-B12 could be a sign of severe, even life-endangering diseases such hematologic complications and numerous tumour types. In this work, we shall evaluate the diagnostic values of elevated Vit-B12 levels in 50 cancer patients (solid cancer patients, non-solid cancer) with 36 healthy people as control. The data shows that the elevated Vit-B12 concentration in the cancer patients was attributed, at least partly, to the cancer type or stage. Interestingly,%50 of patients had Vit-B12levels much greater than the upper limit (>489pg/ml), while the 36 control samples (apparent healthy) had normal levels 100%, within the reference intervals (141pg/ml to 489 pg/ml). We have concluded that the elevated serum Vit-B12is not related to diet intake, but most likely result of malignant processes. This work emphasizes that the possible clinical course of hypercobalaminemia should be under attention in the diagnostic process of malignancies.

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Published

2016-09-20

How to Cite

Assessment on Elevated Serum Vitamin B 12 Level in Cancer Patients at Hiwa Hospital. (2016). Journal of Zankoy Sulaimani - Part A, 18(3), 107-112. https://doi.org/10.17656/jzs.10539