Hepatitis A Seropositivity among Children and Students Under 18 Years Old in Sulaimani Governorate-Kurdistan Regional Government

Authors

  • Salih A. Hama Biology Department, School of Science, University of Sulaimani, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10582

Keywords:

Anti-IgG, Anti IgM, HAV, Oral-fecal route, Socioeconomic status

Abstract

To find the rates of anti-Hepatitis A Virus (HAV) IgG and IgM seropositivity among less than 18 years-old persons, 328 cases were tested by ELISA in Sulaimani Governorates, Iraqi Kurdistan region. It was observed that 47.86% cases were seropositive for anti-HAV IgG whereas only 16.15% were positive for anti-HAV IgM. Sex showed no significant effects on positive results for both IgG and IgM (p = 435, 0.891) respectively. The highest rate of anti- IgG seropositivity was among cases with more than 12 years-old (80.82%) while the highest rate for anti-IgM was among 5-8 years old (2.89%). The age showed noticeable effects on anti-IgG seropositivity (p = 0.000) unlike anti-IgM (p = 0.521). The child educational level also showed a significant effect on anti-IgG (p = 0.000) and anti-IgM (p = 0.0022). It was noticed that the well water has a significant effect on anti-IgM seropositivity (p = 0.027) among tested cases, while other sources showed no effects on the results (p>0.05). Family education showed significant effects on the anti-IgM seropositivity (p = 0.0022) unlike anti-IgG (p = 0.713). Moreover, it was concluded that the living places and family sizes showed significant effects on both anti-IgG and IgM seropositivity (p = 0.0022 and 0.0020) respectively for living places and (p = 0.0019 and 0.047) for family size). Socioeconomic status also significantly effective on anti-IgG (p = 0.0008) and anti-IgM seropositivity (p = 0.0078). The jaundice history showed valuable effects on anti-HAV IgG (p = 0.0207) and IgM seropositivity (p = 0.0017).

References

Krugman, S., J. P. Giles and J. Hammond. "Infectious hepatitis. Evidence for two distinctive clinical, epidemiological and immunological types of infection". J. Am. Med. Assoc., Vol. 200, pp. 365-373 (1967). DOI: https://doi.org/10.1001/jama.200.5.365

Rueckert, R. R. and E. Wimmer. "Systematic nomenclature of picornavirus proteins". J. Virol., Vol. 50, pp. 957-959 (1984). DOI: https://doi.org/10.1128/jvi.50.3.957-959.1984

Melnick, J. L. "Properties and classification of hepatitis A virus". Vaccine, Vol. 10(Suppl. 1), pp. S24-S26. (1992). DOI: https://doi.org/10.1016/0264-410X(92)90536-S

Cromeans, T., M. D. Sobsey, and H. A. Fields. "Development of a plaque assay for a cytopathic, rapidly replicating isolate of hepatitis A virus". J. Med. Virol., Vol. 22, pp. 45-56. (1987). DOI: https://doi.org/10.1002/jmv.1890220107

Lemon, S. M. "Hepatitis A virus: Current concepts of the molecular virology, immunobiology, and approaches to vaccine development". Rev. Med. Virol., Vol. 2, pp. 73-87. (1992). DOI: https://doi.org/10.1002/rmv.1980020204

Cliver, D. O. "Vehicular transmission of hepatitis A". Public Health Rev., Vol. 13, pp. 235-292. (1985).

Ross, B. C. and D. A. Anderson. "Characterization of hepatitis A virus capsid proteins with antisera raised to recombinant antigens". J. Virol. Meth., Vol. 32, pp. 213-220. (1991). DOI: https://doi.org/10.1016/0166-0934(91)90052-2

Akriviadis, E. A. and A. G. Redeker. "Fulminant hepatitis A in intravenous drug users with chronic liver disease". Ann. Intern. Med., Vol. 110, pp. 838-839. (1989). DOI: https://doi.org/10.7326/0003-4819-110-10-838

Hadler, S. C., H. M. Webster, J. J. Erben, J. E. Swanson and J. E. Maynard. "Hepatitis A in day-care centers. A community-wide assessment". New Engl. J. Med., Vol. 302, pp. 1222-1227. (1980). DOI: https://doi.org/10.1056/NEJM198005293022203

Lednar, W. M., S. M. Lemon, J. W. Kirkpatrick, R. R. Redfield, M. L. Fields and P. W. Kelley. "Frequency of illness associated with epidemic hepatitis A virus infections in adults". Am. J. Epidemiol., Vol. 122, pp. 226-33. (1985). DOI: https://doi.org/10.1093/oxfordjournals.aje.a114093

Hadler, S. C. "Global Impact of Hepatitis A Infection: Changing Patterns. In: Hollinger, F.B., S.M. Lemon and H.S". Margolis (Eds.), Williams and Wilkins, Baltimer (1991).

Mackiewicz, V., A. M. Roque-Afonso, E. Marchadier, E. Nicand, L. Fki-Berrajah and E. Dussaix. "Rapid investigation of hepatitis A virus outbreak by single-strand conformation polymorphism analysis". J. Med. Virol., Vol. 76, pp. 271-278. (2005). DOI: https://doi.org/10.1002/jmv.20355

Vitral, C. L., F. L. N. Ospina, S. Artimos, J. G. Melgaço, O. G. Cruz, V. S. de Paula, S. B. Luz, M. Freire, L. P. Gaspar, L. A. Amado, E. M. Engstrom, C. D. F. M. Fortes, T. C. de Souza, M. N. Dias, A. M. C. Gaspar and F. J. D. Souto. "Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil". Mem. Inst. Oswaldo. Cruz. Rio de Janeiro, Vol. 107, No. 5, pp. 652-658. (2012). DOI: https://doi.org/10.1590/S0074-02762012000500012

Jacobsen, K. H. and S. T. Wiersma. "Hepatitis A virus seroprevalence by age and world region (1990 and 2005)". Vaccine, Vol. 41, pp. 6653-6657. (2010). DOI: https://doi.org/10.1016/j.vaccine.2010.08.037

Salama, I. I., S. M. Samy, A. I. Hassanin and A. L. Abou Ismael. "Seroprevalence of hepatitis A among children of different socioeconomic status in Cairo". Health Rev. La Mediterranee Oreintale, Vol. 13, No. 6, pp. 1256-1264. (2007). DOI: https://doi.org/10.26719/2007.13.6.1256

Yassin, K., R. Awad, A. Tebi, A. Queder and U. Laaser. "The epidemiology of hepatitis A infection in Palestine: A universal vaccination programme is not yet needed". Epidemiol. Infect. Vol. 127, No. 2, pp. 335-339. (2001). DOI: https://doi.org/10.1017/S0950268801005970

Antaki, N. and M. K. Kebbewar. "Hepatitis A seroprevalence rates in Syria". Trop. Doct. Vol.30, No. 2, pp. 99-101. (2000). DOI: https://doi.org/10.1177/004947550003000215

Das, K., A. Jain, S. Gupta, S. Kapoor, R. K. Gupta, A. Chakravorty et al. "The changing epidemiology pattern of Hepatitis A in an Urban Population in India: Emergence of a trend similar to the European countries". Eur. J. Epidemiol., Vol. 16, No. 6, pp. 507-510. (2000). DOI: https://doi.org/10.1023/A:1007628021661

Fix, A. D., O. S. Martin, L. Gallicchio, P. A. Vial and R. Lagos. "Age-specific prevalence of antibodies to Hepatitis A in Santiago, Chile: Risk factors and shift in age of infection among children and young adults". Am. J. Trop. Med. Hyg., Vol. 66, No. 5, pp. 628-632. (2002). DOI: https://doi.org/10.4269/ajtmh.2002.66.628

Khalil, M., et al. "Childhood epidemiology of Hepatitis A virus in Riyadh, Saudi Arabia". Anna. Saudi Med., Vol. 18m No. 1, pp. 18-21 (1998). DOI: https://doi.org/10.5144/0256-4947.1998.18

Ciaccia, M. C. C., R. C. Moreira, A. A. Ferraro, M. F. Lemos, G. Porta and I. T. Oba. "Epidemiological and serological aspects of hepatitis A among children and teenagers in the city of Santos: A cross-sectional study". Sao Paulo Med J. Vol. 130, No. 4, pp. 230-235. (2012). DOI: https://doi.org/10.1590/S1516-31802012000400005

Redlinger, T., K. O'Rourke, and J. Van Derslice. "Hepatitis A among Schoolchildren in a US-Mexico border community". Am. J. Publ. Health, Vol. 87, No. 10. pp. 1715-1717. (1997). DOI: https://doi.org/10.2105/AJPH.87.10.1715

Arvas, G, A. Bora, T. Özsari, B. Kaya and G. Açikgöz. "Investigation of Hepatitis A seropositivity in children with different age groups in Igdir, Turkey". Comp. Res. J. Med. Med. Sci., Vol. 2, No. 1, pp. 8-13. (2014).

Kazemi, S. A., M. Mahram, A. Koosha and H. R. Amirmoghaddami. "Seroprevalence of Hepatitis A in 7-10 year-old children". Iran J. Ped., Vol. 17, No. 1, pp. 47-51. (2007).

Published

2017-03-20

How to Cite

Hepatitis A Seropositivity among Children and Students Under 18 Years Old in Sulaimani Governorate-Kurdistan Regional Government. (2017). Journal of Zankoy Sulaimani - Part A, 19(1), 27-34. https://doi.org/10.17656/jzs.10582