Effectiveness of the Platelet Rich Fibrin with Suture and without Suture on Postoperative Complications Following Removal of Lower Third Molars

Authors

  • Nezar Sheikh Ahmed Mohammed Oral and Maxillofacial Surgery Department, College of Dentistry, University of Sulaimani, Kurdistan Region, Iraq. Author
  • Nzar Abdulqadr Hamaamin Oral and Maxillofacial Surgery Department, College of Dentistry, University of Sulaimani, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10879

Keywords:

Impacted third molar, Postoperative Complications, Platelet rich fibrin, Suture, Prospective study

Abstract

Background: The removal of impacted 3rd molar is a traumatic surgical procedure that may lead to some postoperative sequelae such as pain, swelling, and trismus. The aim of this study was to evaluate the effects of PRF with suture, and without suture, on post-operative complications after removal of 3rd molars.

Patients and Materials: This study enrolled 60 patients with partially impacted lower third molars at three centers; Postgraduate Clinic- Department of Oral and maxillofacial Surgery/College of Dentistry/ University of Sulaimani, Private Dental and Maxillofacial Clinic, and Maxillofacial Unit of Kalar General Hospital from November of 2021 till April of 2022. They were randomly allocated into 3 groups of 20 patients each. Group Ӏ was managed by PRF with suture, group ӀӀ was managed by PRF without suture and group ӀII was left without PRF and without suture. Pain, swelling, and maximum interincisal mouth opening were evaluated after the procedure at 1st, 3rd and 7th post-operative days.

Results: In terms of pain (p=0.06), trismus (p=0.71), and swelling (p=0.05), there were no statistically significant differences between the study groups and the control group. In contrast to the control group, the values of the three parameters connected to the study groups were lower. In the group of PRF with suture, Visual Analogue Scale (VAS) pain scores on the 3rd and 7th days were significantly (P=0.008 and P=0.038, respectively) less than other groups. Regarding swelling and trismus, there was no significant correlation (P>0.05) between groups.

Conclusions: Application of PRF with and without suture had no significant effects on postoperative complications such as pain, swelling, and trismus following removal of partially impacted third molars.

References

Malkawi Z., Al-Omiri M.K., & Khraisat A. (2011). Risk indicators of postoperative complications following surgical extraction of lower third molars. Medical Principles and Practice. 20(4), 321-325. DOI: https://doi.org/10.1159/000324550

Bouloux G.F., Steed M.B., & Perciaccante V.J. (2007). Complications of third molar surgery. Oral and Maxillofacial Surgery Clinics. 19(1), 117-128. DOI: https://doi.org/10.1016/j.coms.2006.11.013

Gaßling V.L., Açil Y., Springer I.N., Hubert N., & Wiltfang J. (2009). Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 108(1), 48-55. DOI: https://doi.org/10.1016/j.tripleo.2009.02.007

Anitua E., Andia I., Ardanza B., Nurden P., & Nurden A.T. (2004). Autologous platelets as a source of proteins for healing and tissue regeneration. Thrombosis and Haemostasis. 91(1), 4-15. DOI: https://doi.org/10.1160/TH03-07-0440

Valiulis T., Ivanauskas A., & Janužis G. (2021). Does platelet-rich fibrin reduce negative postoperative outcomes in postextraction sockets? Medicinos Mokslai. 9(5), 1-8. DOI: https://doi.org/10.53453/ms.2021.06.1

Saluja H., Dehane V., & Mahindra U. (2011). Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Annals of Maxillofacial Surgery. 1(1), 53-57. DOI: https://doi.org/10.4103/2231-0746.83158

Gupta V., Bains V.K., Singh G., Mathur A., & Bains R. (2011). Regenerative potential of platelet rich fibrin in dentistry: Literature review. Asian Journal of Oral Health and Allied Sciences. 1, 23-8.

Khadtare Y., Aziz A., & Prashant S. (2021). Bilateral direct sinus lift with platelet rich fibrin (PRF) in combination with DFDBA and FDBA: a case report. IP International Journal of Periodontology and Implantology. 1(3), 100-104.

Asutay F., Yolcu Ü., Geçör O., Acar A., Öztürk S., & Malkoç S. (2017). An evaluation of effects of platelet‑rich‑fibrin on postoperative morbidities after lower third molar surgery. Nigerian Journal of Clinical Practice. 20(12), 1531-1536. DOI: https://doi.org/10.4103/1119-3077.181400

Danda A.K., Tatiparthi M.K., Narayanan V., & Siddareddi A. (2010). Influence of primary and secondary closure of surgical wound after impacted mandibular third molar removal on postoperative pain and swelling—a comparative and split mouth study. Journal of Oral and Maxillofacial Surgery. 68(2), 309-312. DOI: https://doi.org/10.1016/j.joms.2009.04.060

Braimah R.O., Ali-Alsuliman D., Taiwo A.O., Ibikunle A.A., Makarami R.M.H., Al-walah A.S., et al. (2021). Surgical difficulty assessment in patients undergoing impacted mandibular third molar extraction. A single center evaluation in Najran, Kingdom of Saudi Arabia. Journal of Dental Research and Review. 8(3),163-167. DOI: https://doi.org/10.4103/jdrr.jdrr_37_21

Downie W., Leatham P., Rhind V., Wright V., Branco J., & Anderson J. (1978). Studies with pain rating scales. Annals of the Rheumatic Diseases. 37(4), 378-81. DOI: https://doi.org/10.1136/ard.37.4.378

Üstün Y., Erdoǧan Ö., Esen E., & Karsli E.D. (2003). Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 96(5), 535-539. DOI: https://doi.org/10.1016/S1079-2104(03)00464-5

Hyland M.E. & Sodergren S.C. (1996). Development of a new type of global quality of life scale, and comparison of performance and preference for 12 global scales. Quality of Life Research. 5(5), 469-480. DOI: https://doi.org/10.1007/BF00540019

Gürler G. & Delilbaşı Ç. (2016). Effects of leukocyte-platelet rich fibrin on postoperative complications of direct sinus lifting. Minerva Stomatologica. 65(4), 207-212.

Dohan D.M., Choukroun J., Diss A., Dohan S.L., Dohan A.J., Mouhyi J., et al. (2006). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 101(3), e37-e44. DOI: https://doi.org/10.1016/j.tripleo.2005.07.008

Al-Hamed F.S., Tawfik M.A.M., & Abdelfadil E. (2017). Clinical effects of platelet-rich fibrin (PRF) following surgical extraction of lower third molar. The Saudi Journal for Dental Research. 8(1-2), 19-25. DOI: https://doi.org/10.1016/j.sjdr.2016.05.002

Pell G.J. (1933). Impacted mandibular third molars: classification and modified techniques for removal. Dental Digest. 39, 330-338.

Winter G.B. (1926). Impacted mandibular third molars. St Louis: American Medical Book.

Singh S., Singh A., Singh S., & Singh R. (2013). Application of PRF in surgical management of periapical lesions. National Journal of Maxillofacial Surgery. 4(1), 94. DOI: https://doi.org/10.4103/0975-5950.117825

Mozzati M., Scoletta M., & Gallarato I. (2007). Clinical application of autologous platelet rich plasma (PRP) in the extraction of third impacted mandibular molar. Revista Romana De Stomatologie. 53(2), 81-89.

Das J., Parambath P., & Arthur A. (2014). Efficacy of platelet rich plasma in third molar impaction surgery, PRP in third molar surgery. Universal Research Journal of Dentistry. 4, 36-43. DOI: https://doi.org/10.4103/2249-9725.127076

Kedarnath N. & Abhilash P. (2011). Role of platelet-rich plasma in healing after impacted mandibular 3rd molar surgery. Journal of Orofacial Research. 1(1), 1-5.

Bello S.A., Olaitan A.A., & Ladeinde A.L. (2011). A randomized comparison of the effect of partial and total wound closure techniques on postoperative morbidity after mandibular third molar surgery. Journal of Oral and Maxillofacial Surgery. 69(6), e24-e30. DOI: https://doi.org/10.1016/j.joms.2011.01.025

Ferreira-Valente M.A., Pais-Ribeiro J.L., & Jensen M.P. (2011). Validity of four pain intensity rating scales. Pain®. 152(10), 2399-2404. DOI: https://doi.org/10.1016/j.pain.2011.07.005

Hjermstad M.J., Fayers P.M., Haugen D.F., Caraceni A., Hanks G.W., & Loge J.H., et al. (2011). Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. Journal of Pain and Symptom Management. 41(6), 1073-1793. DOI: https://doi.org/10.1016/j.jpainsymman.2010.08.016

Thong I.S., Jensen M.P., Miró J., & Tan G. (2018). The validity of pain intensity measures: what do the NRS, VAS, VRS, and FPS-R measure? Scandinavian Journal of Pain. 18(1), 99-107. DOI: https://doi.org/10.1515/sjpain-2018-0012

Kapse S., Surana S., Satish M., Hussain S.E., Vyas S., & Thakur D. (2019). Autologous platelet-rich fibrin: can it secure a better healing? Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 127(1), 8-18. DOI: https://doi.org/10.1016/j.oooo.2018.08.010

Varghese M.P., Manuel S., & LK S.K. (2017). Potential for osseous regeneration of platelet-rich fibrin—A comparative study in mandibular third molar impaction sockets. Journal of Oral and Maxillofacial Surgery. 75(7), 1322-1329. DOI: https://doi.org/10.1016/j.joms.2017.01.035

Trybek G., Rydlińska J., Aniko-Włodarczyk M., & Jaroń A. (2021). Effect of platelet-rich fibrin application on non-infectious complications after surgical extraction of impacted mandibular third molars. International Journal of Environmental Research and Public Health. 18(16), 8249. DOI: https://doi.org/10.3390/ijerph18168249

Kumar N., Prasad K., Ramanujam L., Ranganath K., Dexith J., & Chauhan A. (2015). Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet-rich fibrin: a randomized controlled clinical study. Journal of Oral and Maxillofacial Surgery. 73(6), 1042-1049. DOI: https://doi.org/10.1016/j.joms.2014.11.013

Ozgul O., Senses F., Er N., Tekin U., Tuz H.H., Alkan A., et al. (2015). Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial. Head and Face Medicine. 2015;11(1), 1-5. DOI: https://doi.org/10.1186/s13005-015-0094-5

Singh A., Kohli M., & Gupta N. (2012). Platelet rich fibrin: a novel approach for osseous regeneration. Journal of Maxillofacial and Oral Surgery. 11(4), 430-434. DOI: https://doi.org/10.1007/s12663-012-0351-0

Dutta S.R., Singh P., Passi D., & Patter P. (2015). Mandibular third molar extraction wound healing with and without platelet rich plasma: a comparative prospective study. Journal of Maxillofacial and Oral Surgery. 14(3), 808-815. DOI: https://doi.org/10.1007/s12663-014-0738-1

Nathani D.B., Sequeira J., & Rao B.S. (2015). Comparison of platelet rich plasma and synthetic graft material for bone regeneration after third molar extraction. Annals of Maxillofacial Surgery. 5(2), 213-218. DOI: https://doi.org/10.4103/2231-0746.175762

Simonpieri A., Del Corso M., Vervelle A., Jimbo R., Inchingolo F., Sammartino G., et al. (2012). Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Current Pharmaceutical Biotechnology. 13(7), 1231-1256. DOI: https://doi.org/10.2174/138920112800624472

Dohan Ehrenfest D.M., Pinto N.R., Pereda A., Jiménez P., Corso M.D., Kang B.S., et al. (2018). The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, and fibrin architecture of a leukocyte-and platelet-rich fibrin (L-PRF) clot and membrane. Platelets. 29(2), 171-184. DOI: https://doi.org/10.1080/09537104.2017.1293812

Gülşen U. & Şentürk M.F. (2017). Effect of platelet rich fibrin on edema and pain following third molar surgery: a split mouth control study. BMC Oral Health. 17(1), 1-6. DOI: https://doi.org/10.1186/s12903-017-0371-8

Marenzi G., Riccitiello F., Tia M., di Lauro A., & Sammartino G. (2015). Influence of leukocyte-and platelet-rich fibrin (L-PRF) in the healing of simple postextraction sockets: a split-mouth study. BioMed Research International. 2015, 1-6. DOI: https://doi.org/10.1155/2015/369273

Gay-Escoda C., Gómez-Santos L., Sánchez-Torres A., & Herráez-Vilas J.M. (2015). Effect of the suture technique on postoperative pain, swelling and trismus after removal of lower third molars: A randomized clinical trial. Medicina Oral, Patologia Orally Cirugia Bucal. 20(3), e372-e377. DOI: https://doi.org/10.4317/medoral.20307

Osunde O.D., Saheeb B.D., & Adebola R.A. (2011). Comparative study of effect of single and multiple suture techniques on inflammatory complications after third molar surgery. Journal of Oral and Maxillofacial Surgery. 69(4), 971-976. DOI: https://doi.org/10.1016/j.joms.2010.05.009

Xue P., Wang J., Wu B., Ma Y., Wu F., & Hou R. (2015). Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial. British Journal of Oral and Maxillofacial Surgery. 53(5), 416-420. DOI: https://doi.org/10.1016/j.bjoms.2015.02.001

Maria A., Malik M., & Virang P. (2012). Comparison of primary and secondary closure of the surgical wound after removal of impacted mandibular third molars. Journal of Maxillofacial and Oral Surgery. 11(3), 276-283. DOI: https://doi.org/10.1007/s12663-011-0287-9

Published

2022-12-20

How to Cite

Effectiveness of the Platelet Rich Fibrin with Suture and without Suture on Postoperative Complications Following Removal of Lower Third Molars. (2022). Journal of Zankoy Sulaimani - Part A, 24(2), 31-42. https://doi.org/10.17656/jzs.10879

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