Leukemia Morbidity and Mortality among Children Admitted to Hiwa Hospital from January 2015 to January 2022: A Retrospective Study

Authors

  • Pary Mohammad Azize Department of Nursing, Sulaimani Polytechnic University, Sulaimani, Kurdistan Region, Iraq. Author

DOI:

https://doi.org/10.17656/jzs.10942

Keywords:

Leukemia, risk factors, age, gender, morbidity, mortality

Abstract

In 2016, 1 out of 3 cancer patients aged less than 20 years old were diagnosed with leukemia. Globally, leukemia is the most common malignancy in children and teenagers. This study aimed to determine leukemia cases' morbidity and mortality rates and their distribution in different areas of Sulaimani, Iraq, for seven years. This retrospective study is based on the Hospital Information System children's leukemia data from January 2015 to January 2022 at the Hematology Department, Hiwa Oncology/Hematology Hospital, Sulaimani, Iraq, using a Cox regression model (Cox, 1972). In 616 recorded children leukemia cases during seven years, 549(89.1%) of them were alive, and only 67(10.9%) died. The majority were male, aged between 5-10 years. Nearly 222(36%) of the patients had A+ blood group, followed by 210(34.1%) O+ blood group, while the minority was AB- group. The study result shows that age, and blood group, were risk factors for increasing leukemia chances by Exp (-0.074) =0.929. Leukemia morbidity rises significantly with age, and leukemia's morbidity rate increases gradually with time. While mortality was decreased. Depends on the forecasting for the next 10 years. Both ALL and AML were common malignancies among diagnosed children.

References

Clarke R.T., Van den Bruel A., Bankhead C., Mitchell C.D., Phillips B., Thompson M.J. (2016). Clinical

presentation of childhood leukaemia: a systematic review and meta-analysis. Archives of Disease in

Childhood. 101(10):894-901.

Ahmad S.M., Ahmed B.S., Khidhir K.G., Rahman H.S. (2022). Prospective quantitative gene expression

analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic

leukemia. PeerJ. 10:e13489.

Davis A., Viera A.J., Mead M.D. (2014). Leukemia: an overview for primary care. American Family

Physician. 89(9):731-738.

Cazzola A., Cazzaniga G., Biondi A., Meneveri R., Brunelli S., Azzoni E. (2021). Prenatal origin of pediatric

leukemia: lessons from hematopoietic development. Frontiers in Cell and Developmental Biology. 8:618164.

Terwilliger T., Abdul-Hay M. (2017). Acute lymphoblastic leukemia: a comprehensive review and 2017 DOI: https://doi.org/10.1038/bcj.2017.53

update. Blood Cancer Journal. 7(6):e577-e577.

Legano L., McHuhg M., Palusci V. (2009). Current problems in pediatric and adolescent health care. Child

Abuse and Neglect. 39(2):31-57.

Creutz ig U., van Den Heuvel-Eibrink M.M., Gibson B., Dworzak M.N., Adachi S., de Bont E., Harbott J.,

Hasle H., Johnston D., Kinoshita A. (2012). Diagnosis and management of acute myeloid leukemia in children

and adolescents: recommendations from an international expert panel. Blood, The Journal of the American

Society of Hematology. 120(16):3187-3205.

Ward Z.J., Yeh J.M., Bhakta N., Frazier A.L., Atun R. (2019). Estimating the total incidence of global

childhood cancer: a simulation-based analysis. The Lancet Oncology. 20(4):483-493.

Yonan A., Jacques C., Fletcher T., Suk-In T., Campbell R.B. (2022). An Overview of Conventional Drugs

and Nano Therapeutic Options for the Treatment and Management of Pediatric Acute Lymphoblastic

Leukemia. Anti-cancer Agents in Medicinal Chemistry. 22(18):3050 - 3061.

Habib O., JG H., JM A.-D. (2016). Cancer of children in Basrah-Iraq: Person and time characteristics. The

Medical Journal of Basrah University. 34(2):77-85.

Karim Z.A., Khidhir K.G., Ahmed R.A., Hassan H.A., Karim D.O. (2016). Leukemia Study in 11.

Sulaymaniyah Province, Kurdistan, Iraq. Chinese Medical Journal. 129(02):244-245.

Khoshnaw N, Mohammed HA, Abdullah DA. (2015). Patterns of cancer in Kurdistan - results of eight

years cancer registration in Sulaymaniyah Province-Kurdistan-Iraq. Asian Pac J Cancer Prev. 16:8525–31.

Forsythe A., Breland T., Majumdar S., Elkin T.D., Johnson D., Megason G. (2010). Gender differences in

incidence rates of childhood B-precursor acute lymphocytic leukemia in Mississippi. Journal of Pediatric

Oncology Nursing. 27(3):164-167.

AL- Hashimi M Y, (2021). Incidence of Childhood Leukemia in Iraq, 2000-2019. Asian Pac J Cancer DOI: https://doi.org/10.31557/APJCP.2021.22.11.3663

Prev. 22(11):3663-3670

Gupta S., Teachey D.T., Chen Z., Rabin K.R., Dunsmore K.P., Larsen E.C., Maloney K.W., Mattano Jr

L.A., Winter S.S., Carroll A.J. (2022). Sex‐based disparities in outcome in pediatric acute lymphoblastic

leukemia: a Children’s Oncology Group report. Cancer. 128(9):1863-1870.

Steliarova-Foucher E., Colombet M., Ries L.A., Moreno F., Dolya A., Bray F., Hesseling P., Shin H.Y.,

Stiller C.A., Bouzbid S. (2017). International incidence of childhood cancer, 2001–10: a population-based

registry study. The Lancet Oncology. 18(6):719-731. DOI: https://doi.org/10.1016/S1470-2045(05)70361-2

Erdmann F., Li T., Luta G., Giddings B.M., Alvarado G.T., Steliarova-Foucher E., Schüz J., Mora A.M.

(2018). Incidence of childhood cancer in Costa Rica, 2000–2014: an international perspective. Cancer

Epidemiology. 56:21-30.

Das S., Paul D.K., Anshu K., Bhakta S. (2017). Childhood cancer incidence in India betweem 2012 and

: Report of a population-based cancer registry. Indian Pediatrics. 54(12):1033-1036.

Asthana S., Labani S., Mehrana S., Bakhshi S. Incidence of childhood leukemia and lymphoma in India.

Pediatric Hematology Oncology Journal. 2018;3(4):115-120. DOI: https://doi.org/10.1016/j.phoj.2017.12.004

Barrington‐Trimis J.L., Cockburn M., Metayer C., Gauderman W.J., Wiemels J., McKean‐Cowdin R.

(2017). Trends in childhood leukemia incidence over two decades from 1992 to 2013. International Journal

of Cancer. 140(5):1000-1008.

Stjernfelt K.-J., von Stedingk K., Wiebe T., Hjorth L., Kristoffersson U., Stenmark-Askmalm M., Olsson

H., Øra I. (2020). Increased cancer risk in families with pediatric cancer is associated with gender, age,

diagnosis, and degree of relation to the child. Cancer Epidemiology, Biomarkers & Prevention. 29(11):2171-

Yaseen O.K. (2015). Relationship between Age, Gender and ABO Blood Groups in Childhoods Cancer.

Diyala Journal of Medicine. 8(2):65-68.

Ghali H.H., Nayeef A.M., Hameed A.H., Fawzi G.M. (2017). Relationship between ABO and Rh Blood

Groups withChildhood Acute Lymphoblastic Leukemia. IOSR Journal of Research & Method in Education.

(2):86-89.

Abd-Allateef M.H. (2021). Blood Groups Relationship with Incidence of Malignancy in Children,

University of Diyala;

Tavasolian F., Abdollahi E., Vakili M., Amini A. (2014). Relationship between ABO blood group and

Acute Lymphoblastic Leukemia. Iranian Journal of Pediatric Hematology and Oncology. 4(1):1-4.

Lins M.M., Santos M.d.O., de Albuquerque M.d.F.P.M., de Castro C.C.L., Mello M.J.G., de Camargo B.

(2017). Incidence and survival of childhood leukemia in Recife, Brazil: A population‐based analysis. Pediatric

Blood & Cancer. 64(8):e26391.

Petridou E.T., Dimitrova N., Eser S., Kachanov D., Karakilinc H., Varfolomeeva S., Belechri M., Baka

M., Moschovi M., Polychronopoulou S. (2013). Childhood leukemia and lymphoma: time trends and factors

affecting survival in five Southern and Eastern European Cancer Registries. Cancer Causes & Control.

(6):1111-1118.

Hunger S.P., Mullighan C.G. (2015). Acute lymphoblastic leukemia in children. New England Journal of DOI: https://doi.org/10.1056/NEJMra1400972

Medicine. 373(16):1541-1552

Jaime-Pérez J.C., García-Arellano G., Herrera-Garza J.L., Marfil-Rivera L.J., Gómez-Almaguer D. (2019).

Revisiting the complete blood count and clinical findings at diagnosis of childhood acute lymphoblastic

leukemia: 10-year experience at a single center. Hematology, Transfusion and Cell Therapy. 41:57-61.

Amen K.M. Abdullah O.S., . Amin A S, Mohamed Z A. , Bestoon B, et al.,. (2020). Cancer Incidence in

the Kurdistan Region of Iraq: Results of a Seven-Year Cancer Registration in Erbil and Duhok Governorates,

Asian Pac J Cancer Prev. 23(2): 601–615.

Published

2023-12-20

How to Cite

Leukemia Morbidity and Mortality among Children Admitted to Hiwa Hospital from January 2015 to January 2022: A Retrospective Study. (2023). Journal of Zankoy Sulaimani - Part A, 25(2), 10. https://doi.org/10.17656/jzs.10942